{"id":134741,"date":"2024-04-28T12:01:25","date_gmt":"2024-04-28T04:01:25","guid":{"rendered":"https:\/\/docs.pingcode.com\/ask\/ask-ask\/134741.html"},"modified":"2024-04-28T12:01:27","modified_gmt":"2024-04-28T04:01:27","slug":"%e5%8c%bb%e8%8d%af%e6%95%b0%e6%8d%ae%e5%ba%93%e6%9c%89%e5%93%aa%e4%ba%9b","status":"publish","type":"post","link":"https:\/\/docs.pingcode.com\/ask\/ask-ask\/134741.html","title":{"rendered":"\u533b\u836f\u6570\u636e\u5e93\u6709\u54ea\u4e9b"},"content":{"rendered":"

\"\u533b\u836f\u6570\u636e\u5e93\u6709\u54ea\u4e9b\"<\/p>\n

\u533b\u836f\u6570\u636e\u5e93\u662f\u6536\u96c6\u3001\u5b58\u50a8\u3001\u7ba1\u7406\u3001\u5206\u6790\u533b\u836f\u76f8\u5173\u6570\u636e\u7684\u91cd\u8981\u5de5\u5177\u3002\u5b83\u4eec\u5728\u836f\u7269\u7814\u53d1\u3001\u4e34\u5e8a\u8bd5\u9a8c\u3001\u836f\u54c1\u76d1\u7ba1\u4ee5\u53ca\u533b\u7597\u5065\u5eb7\u670d\u52a1\u4e2d\u626e\u6f14\u7740\u5173\u952e\u89d2\u8272\u3002\u4e3b\u8981\u7684\u533b\u836f\u6570\u636e\u5e93\u5305\u62ecPubChem\u3001DrugBank\u3001ClinicalTrials.gov\u3001PubMed\u53caCochrane Library<\/strong>\u3002\u5176\u4e2d\uff0cPubChem<\/strong> \u63d0\u4f9b\u5173\u4e8e\u5316\u5b66\u5206\u5b50\u548c\u5176\u6d3b\u6027\u7684\u5927\u91cf\u4fe1\u606f\uff0c\u5bf9\u4e8e\u836f\u7269\u5316\u5b66\u548c\u5206\u5b50\u751f\u7269\u5b66\u7814\u7a76\u5c24\u4e3a\u91cd\u8981\u3002<\/p>\n<\/p>\n

\u4e00\u3001PubChem<\/h3>\n<\/p>\n

PubChem<\/strong> \u662f\u7531\u7f8e\u56fd\u56fd\u5bb6\u751f\u7269\u6280\u672f\u4fe1\u606f\u4e2d\u5fc3\uff08NCBI\uff09\u8fd0\u8425\u7684\u4e00\u4e2a\u9762\u5411\u79d1\u7814\u4eba\u5458\u7684\u514d\u8d39\u5316\u5b66\u6570\u636e\u5e93\u3002\u5b83\u63d0\u4f9b\u4e86\u8d85\u8fc7\u4e00\u5343\u4e07\u79cd\u5316\u5408\u7269\u7684\u4fe1\u606f\uff0c\u5176\u4e2d\u5305\u62ec\u5316\u5b66\u7ed3\u6784\u3001\u751f\u7269\u6d3b\u6027\u3001\u5b89\u5168\u6027\u548c\u4e13\u5229\u6570\u636e\u3002PubChem\u5e93\u5206\u4e3a\u4e09\u4e2a\u4e3b\u8981\u90e8\u5206\uff1a\u5316\u5408\u7269\uff08Compound\uff09\u3001\u7269\u8d28\uff08Substance\uff09\u548c\u751f\u7269\u6d3b\u6027\uff08BioAssay\uff09\u3002\u5316\u5408\u7269\u90e8\u5206\u63d0\u4f9b\u6709\u5173\u5355\u4e00\u7eaf\u51c0\u5316\u5b66\u5b9e\u4f53\u7684\u4fe1\u606f\uff0c\u7269\u8d28\u90e8\u5206\u5305\u542b\u5404\u79cd\u6765\u6e90\u7684\u6df7\u5408\u7269\u548c\u5316\u5408\u7269\u7684\u63cf\u8ff0\uff0c\u800c\u751f\u7269\u6d3b\u6027\u90e8\u5206\u5219\u5305\u542b\u5b9e\u9a8c\u5ba4\u6d4b\u8bd5\u8bb0\u5f55\uff0c\u8fd9\u4e9b\u6d4b\u8bd5\u8bb0\u5f55\u53cd\u6620\u4e86\u5316\u5408\u7269\u5bf9\u4e8e\u7279\u5b9a\u751f\u7269\u9776\u6807\u7684\u5f71\u54cd\u3002<\/p>\n<\/p>\n

\u4e8c\u3001DrugBank<\/h3>\n<\/p>\n

DrugBank<\/strong> \u662f\u4e00\u4e2a\u72ec\u7279\u7684\u751f\u7269\u4fe1\u606f\u5b66\u548c\u836f\u7406\u5b66\u8d44\u6e90\uff0c\u5b83\u7ed3\u5408\u4e86\u8be6\u5c3d\u7684\u836f\u7269\u6570\u636e\uff08\u5982\u5316\u5b66\u3001\u836f\u7406\u5b66\u3001\u5904\u65b9\u548c\u836f\u4ee3\u52a8\u529b\u5b66\u7b49\u4fe1\u606f\uff09\u4e0e\u7efc\u5408\u7684\u836f\u7269\u9776\u6807\uff08\u4f8b\u5982\u53d7\u4f53\u3001\u9176\u7b49\uff09\u4fe1\u606f\u3002DrugBank\u5e7f\u6cdb\u5e94\u7528\u4e8e\u836f\u7269\u5316\u5b66\u7814\u7a76\u548c\u5f00\u53d1\uff0c\u662f\u79d1\u7814\u5de5\u4f5c\u8005\u3001\u836f\u5b66\u5bb6\u548c\u533b\u7597\u4e13\u4e1a\u4eba\u5458\u7684\u5b9d\u8d35\u8d44\u6e90\u3002\u6b64\u5916\uff0c\u6570\u636e\u5e93\u8fd8\u63d0\u4f9b\u4e86\u836f\u7269\u7684\u4f5c\u7528\u673a\u5236\u3001\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u3001\u836f\u7269\u5206\u5b50\u7684\u4e09\u7ef4\u7ed3\u6784\u7b49\u91cd\u8981\u4fe1\u606f\u3002<\/p>\n<\/p>\n

\u4e09\u3001ClinicalTrials.gov<\/h3>\n<\/p>\n

ClinicalTrials.gov<\/strong> \u662f\u7f8e\u56fd\u56fd\u7acb\u533b\u5b66\u56fe\u4e66\u9986\u7ef4\u62a4\u7684\u4e00\u4e2a\u6570\u636e\u5e93\uff0c\u5b83\u63d0\u4f9b\u4e86\u5168\u7403\u8303\u56f4\u5185\u7684\u4e34\u5e8a\u7814\u7a76\u8bd5\u9a8c\u4fe1\u606f\u3002\u8be5\u5e73\u53f0\u8986\u76d6\u4e86\u5e7f\u6cdb\u7684\u75be\u75c5\u548c\u6761\u4ef6\uff0c\u5e76\u5305\u542b\u8bd5\u9a8c\u7684\u8bbe\u8ba1\u3001\u53c2\u4e0e\u8005\u8d44\u683c\u3001\u5730\u70b9\u3001\u836f\u7269\u5242\u91cf\u548c\u6cbb\u7597\u7ed3\u679c\u7b49\u6570\u636e\u3002\u4e34\u5e8a\u4e13\u4e1a\u4eba\u5458\u548c\u7814\u7a76\u4eba\u5458\u5229\u7528\u8fd9\u4e2a\u6570\u636e\u5e93\u6765\u53d1\u73b0\u76f8\u5173\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3001\u8ffd\u8e2a\u836f\u7269\u7814\u53d1\u8fdb\u7a0b\uff0c\u540c\u65f6\u4e5f\u4fc3\u8fdb\u4e86\u60a3\u8005\u5bf9\u6b63\u5728\u8fdb\u884c\u7684\u7814\u7a76\u7684\u4e86\u89e3\u548c\u53c2\u4e0e\u3002<\/p>\n<\/p>\n

\u56db\u3001PubMed<\/h3>\n<\/p>\n

PubMed<\/strong> \u662f\u4e00\u4e2a\u514d\u8d39\u7684\u641c\u7d22\u5f15\u64ce\uff0c\u4e3b\u8981\u7528\u4e8e\u68c0\u7d22MEDLINE\u6536\u5f55\u7684\u751f\u7269\u533b\u5b66\u6587\u732e\u3002\u8fd9\u662f\u4e16\u754c\u4e0a\u6700\u5927\u7684\u533b\u836f\u5065\u5eb7\u79d1\u5b66\u6587\u732e\u6570\u636e\u5e93\uff0c\u5305\u542b\u4e86\u4ece1946\u5e74\u5230\u76ee\u524d\u7684\u8d85\u8fc73000\u4e07\u7bc7\u6587\u732e\u5f15\u7528\u548c\u6458\u8981\u3002PubMed\u4e0d\u4ec5\u88ab\u533b\u7597\u4fdd\u5065\u4e13\u4e1a\u4eba\u5458\u5e7f\u6cdb\u7528\u4e8e\u6587\u732e\u68c0\u7d22\uff0c\u800c\u4e14\u8fd8\u5bf9\u533b\u7597\u51b3\u7b56\u548c\u5b66\u672f\u7814\u7a76\u6709\u7740\u81f3\u5173\u91cd\u8981\u7684\u5f71\u54cd\u3002\u5b83\u7684\u4e3b\u8981\u5185\u5bb9\u5305\u62ec\u4e34\u5e8a\u7814\u7a76\u62a5\u544a\u3001\u5ba1\u67e5\u6587\u7ae0\u3001\u6307\u5357\u4ee5\u53ca\u57fa\u7840\u751f\u7269\u533b\u5b66\u7814\u7a76\u8bba\u6587\u3002<\/p>\n<\/p>\n

\u4e94\u3001Cochrane Library<\/h3>\n<\/p>\n

Cochrane Library<\/strong> \u662f\u4e00\u4e2a\u6743\u5a01\u7684\u533b\u5b66\u548c\u5065\u5eb7\u4fdd\u5065\u6570\u636e\u5e93\uff0c\u5b83\u4e13\u6ce8\u4e8e\u6536\u96c6\u548c\u603b\u7ed3\u81f4\u529b\u4e8e\u8bc1\u636e\u533b\u5b66\u7684\u7cfb\u7edf\u8bc4\u4ef7\u4e0e\u5143\u5206\u6790\u3002\u8fd9\u4e2a\u5e93\u662f\u533b\u5e08\u3001\u62a4\u7406\u4eba\u5458\u3001\u60a3\u8005\u3001\u7814\u7a76\u4eba\u5458\u4ee5\u53ca\u653f\u7b56\u5236\u5b9a\u8005\u5bfb\u627e\u9ad8\u8d28\u91cf\u8bc1\u636e\u4ee5\u652f\u6301\u4e34\u5e8a\u548c\u536b\u751f\u51b3\u7b56\u7684\u91cd\u8981\u8d44\u6e90\u3002Cochrane Library\u7684\u6838\u5fc3\u4ea7\u54c1\u662fCochrane Reviews\uff0c\u8fd9\u4e9b\u7efc\u8ff0\u662f\u901a\u8fc7\u4e25\u683c\u7684\u65b9\u6cd5\u5b66\u5bf9\u533b\u7597\u5e72\u9884\u63aa\u65bd\u6709\u6548\u6027\u8fdb\u884c\u8bc4\u4ef7\u7684\u7ed3\u679c\u3002<\/p>\n<\/p>\n

\u516d\u3001\u5176\u4ed6\u533b\u836f\u6570\u636e\u5e93<\/h3>\n<\/p>\n

\u9664\u4e86\u4e0a\u8ff0\u6570\u636e\u5e93\u5916\uff0c\u8fd8\u6709\u4e00\u4e9b\u7279\u5b9a\u529f\u80fd\u7684\u533b\u836f\u6570\u636e\u5e93\uff0c\u5b83\u4eec\u4e5f\u5728\u7279\u5b9a\u9886\u57df\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\u3002\u4f8b\u5982\uff1a<\/p>\n<\/p>\n

1. EMBASE<\/h4>\n<\/p>\n

\u662f\u4e00\u4e2a\u8986\u76d6\u836f\u7406\u5b66\u548c\u751f\u7269\u533b\u5b66\u9886\u57df\u5e7f\u6cdb\u7684\u56fd\u9645\u6587\u732e\u6570\u636e\u5e93\uff0c\u7279\u522b\u5f3a\u8c03\u6b27\u6d32\u6587\u732e\u3002<\/p>\n<\/p>\n

2. UpToDate<\/h4>\n<\/p>\n

\u63d0\u4f9b\u57fa\u4e8e\u8bc1\u636e\u7684\u4e34\u5e8a\u51b3\u7b56\u652f\u6301\u8d44\u6e90\uff0c\u7279\u522b\u53d7\u6b22\u8fce\u4e8e\u4e34\u5e8a\u5b9e\u8df5\u4eba\u5458\u3002<\/p>\n<\/p>\n

3. DAI<\/a>lyMed<\/h4>\n<\/p>\n

\u63d0\u4f9b\u7f8e\u56fd\u5e02\u552e\u836f\u54c1\u7684\u6700\u65b0\u6807\u7b7e\u4fe1\u606f\uff0c\u5305\u62ecFDA\u6279\u51c6\u7684\u836f\u54c1\u6807\u7b7e\u3002<\/p>\n<\/p>\n

4. TOXNET<\/h4>\n<\/p>\n

\u662f\u4e00\u5957\u5173\u4e8e\u6709\u6bd2\u5316\u5b66\u54c1\u3001\u73af\u5883\u5065\u5eb7\u548c\u6bd2\u7269\u5b66\u6570\u636e\u5e93\u3002<\/p>\n<\/p>\n

\u56e0\u5e94\u4e0d\u540c\u7684\u9700\u6c42\uff0c\u7814\u7a76\u8005\u3001\u4e34\u5e8a\u533b\u751f\u548c\u533b\u836f\u4e13\u4e1a\u4eba\u58eb\u5e94\u6839\u636e\u7814\u7a76\u76ee\u7684\u548c\u6240\u9700\u7684\u4fe1\u606f\u7c7b\u578b\u9009\u62e9\u5408\u9002\u7684\u533b\u836f\u6570\u636e\u5e93\u3002\u6bcf\u4e2a\u6570\u636e\u5e93\u90fd\u6709\u5176\u7279\u5b9a\u7684\u7126\u70b9\u548c\u4f18\u52bf\uff0c\u5728\u8fdb\u884c\u533b\u5b66\u548c\u836f\u5b66\u7814\u7a76\u65f6\u7684\u7efc\u5408\u8fd0\u7528\u80fd\u591f\u63d0\u5347\u7814\u7a76\u7684\u5168\u9762\u6027\u548c\u51c6\u786e\u6027\u3002<\/p>\n<\/p>\n

\u76f8\u5173\u95ee\u7b54FAQs\uff1a<\/strong><\/h2>\n

1. \u533b\u836f\u6570\u636e\u5e93\u6709\u54ea\u4e9b\u5e38\u7528\u7684\uff1f<\/strong>
\n\u5f53\u6d89\u53ca\u5230\u533b\u836f\u6570\u636e\u5e93\u65f6\uff0c\u5e38\u89c1\u7684\u51e0\u4e2a\u5305\u62ecPubMed\u3001Embase\u3001Scopus\u3001Web of Science\u3001CNKI\u3001Wanfang\u3001VIP\u7b49\u3002\u8fd9\u4e9b\u6570\u636e\u5e93\u6536\u5f55\u4e86\u5927\u91cf\u533b\u5b66\u6587\u732e\uff0c\u7814\u7a76\u62a5\u9053\u548c\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\uff0c\u63d0\u4f9b\u4e86\u4e30\u5bcc\u7684\u4fe1\u606f\u8d44\u6e90\u7528\u4e8e\u533b\u836f\u7814\u7a76\u548c\u4e34\u5e8a\u5b9e\u8df5\u3002<\/p>\n

2. \u5e38\u7528\u7684\u533b\u836f\u6570\u636e\u5e93\u6709\u54ea\u4e9b\u4f18\u52bf\uff1f<\/strong>
\n\u533b\u836f\u6570\u636e\u5e93\u7684\u4f18\u52bf\u4e3b\u8981\u4f53\u73b0\u5728\u4ee5\u4e0b\u51e0\u4e2a\u65b9\u9762\u3002\u9996\u5148\uff0c\u8fd9\u4e9b\u6570\u636e\u5e93\u6536\u5f55\u4e86\u5927\u91cf\u7684\u533b\u5b66\u6587\u732e\uff0c\u53ef\u4ee5\u6ee1\u8db3\u7814\u7a76\u8005\u548c\u533b\u751f\u5bf9\u6700\u65b0\u4fe1\u606f\u7684\u9700\u6c42\u3002\u5176\u6b21\uff0c\u8fd9\u4e9b\u6570\u636e\u5e93\u63d0\u4f9b\u4e86\u591a\u79cd\u641c\u7d22\u548c\u7b5b\u9009\u529f\u80fd\uff0c\u4f7f\u7528\u6237\u53ef\u4ee5\u5feb\u901f\u627e\u5230\u6240\u9700\u5185\u5bb9\u3002\u6b64\u5916\uff0c\u4e00\u4e9b\u6570\u636e\u5e93\u8fd8\u63d0\u4f9b\u4e86\u5168\u6587\u4e0b\u8f7d\u548c\u5728\u7ebf\u8ba2\u9605\u7b49\u670d\u52a1\uff0c\u65b9\u4fbf\u7528\u6237\u83b7\u53d6\u5168\u6587\u548c\u8ddf\u8e2a\u6700\u65b0\u8fdb\u5c55\u3002<\/p>\n

3. \u54ea\u4e9b\u533b\u836f\u6570\u636e\u5e93\u9002\u5408\u4e0d\u540c\u7684\u7814\u7a76\u9700\u6c42\uff1f<\/strong>
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