Find Reactions, Proteins and Pathways
Pathway Browser
Visualize and interact with Reactome biological pathways
Analysis Tools
Merges pathway identifier mapping,
over-representation, and expression analysis
AI Chatbot
Meet the React-to-Me AI Chatbot! Designed to answer your questions about Reactome Pathways.
ReactomeFIViz
Designed to find pathways and network patterns related to cancer and other types of diseases
Documentation
Information to browse the database and use its principal tools for data analysis
Reactome Research Spotlight
[September 1, 2026] In their June 2026 Nature research article, "Cortical development dynamics across autism spectrum disorder mouse models", Schwarz et al. find that mutations linked to autism spectrum disorder (ASD) result in transient developmental delay of the brain cortex. A compendium of Reactome-derived protein-protein interactions (PPIs) was one of the resources used to construct a reference PPI network that was then used for network colocalization analysis of differentially expressed genes identified by single-nucleus multi-omic sequencing of brain samples from eleven monogenic mouse ASD models across three developmental stages. The authors show that ASD-linked mutations converge on perturbations of the radial glial cell lineage, with the largest transcriptional differences seen in neurons at early postnatal stages and involving downregulation of synaptic and ion channel-related genes.
Why Reactome
Reactome is a free, open-source, curated and peer-reviewed pathway database. Our goal is to provide intuitive bioinformatics tools for the visualization, interpretation and analysis of pathway knowledge to support basic research, genome analysis, modeling, systems biology and education.
The development of Reactome is supported by a grant from the US National Institutes of Health (U24 HG012198).
Version 97 released on June 30, 2026
Human Pathways
Reactions
Proteins
Small Molecules
Drugs
Literature References
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